![]() ![]() The result of this study is sustained release tablet metformin HCl with matrixes HPMC K4M and chitosan able to float, but it did not form sustained release. Dm Bb Am C Gm G F A D Em Chords for Permata Yang Dicari by De Hearty with song key, BPM, capo transposer, play along with guitar, piano, ukulele & mandolin. The release test showed that all formulas did not meet the requirements dissolution metformin HCl sustained release tablet. Meanwhile, tablet disintegration was the lowest. Secara matematis, suku bunga efektif dapat dicari dengan rumus : 1. The matrixes containing higher HPMC K4M, and lower chitosan showed floating lag time decreased and duration time increased. All tablet formulas showed closed similarity with the requirement physical tablet of United State Pharmacopea (USP) and Farmakope Indonesia reference. The dissolution study had been carried out for 6 hours using USP dissolution apparatus II (paddle) in 900 ml HCl pH 3.0 media at 37☐.50C. The tablets were evaluated of weight variation, drug content, hardness, friability, and in vitro floating and drug release studies. The research aimed to prepare and evaluate of sustained release metformin HCl tablet with floating system. Metformin HCl, lepas lambat, floating Abstract ![]()
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